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How long does it take for avana50 to work is typically fast-acting. It begins to work within 15 to 30 minutes of ingestion, which is faster than many other ED medications. Unlike some other ED medications that may require an hour or more before becoming effective, Avanafil can begin working more rapidly, which is ideal for those who want more spontaneity in sexual activity. Avanafil is a fast-acting PDE5 inhibitor, with effects starting within 15 to 30 minutes and lasting for up to 6 hours. This makes it a good option for those who prefer a medication that works quickly and offers flexibility in timing for sexual activity. Always use Avanafil as prescribed and consult a healthcare provider to ensure it's safe for your individual needs.